Principal Investigator

Assoc. Prof. Dr. Ika Dewi Ana
Universitas Gadjah Mada (UGM), Indonesia

ASEAN Co-Investigator


Japanese Co-Investigator

Prof. Dr. Yasuhiko TABATA
Kyoto University

Awarded year



Collaborative Research Program with Industry (CRI)


Materials Engineering


Bone tissue is one of the most frequently used tissues for transplantation. Annually more than a million patients are treated worldwide for skeletal problems in the field of orthopedic surgery, plastic surgery, maxillofacial surgery and neurosurgery. Autologous bone graft is still considered to be the golden standard of bone grafting materials although patients must undergo the pain and possible complications associated with the harvesting procedure. Allogeneic and xenogeneic bone grafts carry with them a theoretical risk of disease transmission and increased cost. Since synthetic alloplastic materials can be precisely controlled for their physical and biological properties and are not constrained by limitations of additional surgical procedures for their fabrication, they are considered to be the most promising bone grafting materials. To provide the answer to the issue, the basic knowledge on the composition of human bone mineral must be understood. It is known from the previous researches that carbonate apatite (CHA) has been a most likely candidate for bone substitutes with a superior biodegradation. The current project aimed to investigate that dissolution-precipitation method of calcium hydroxide in gelatin system is a simple, cheap, and appropriate alternative to fabricate biomimetic bone-substituting carbonate apatite composite due to its intrinsic osteoconductive properties, which can be further modulated and adjusted by changing the chemical composition of the created set mass and by the inclusion of bone growth stimulating factors with time-dependent release.

Project at glance